Third-Party Tested by Verum Analytics
BPC-157
Body Protection Compound-157, a synthetic pentadecapeptide studied in actin-pathway and angiogenesis research.
Third-Party Tested by Verum Analytics
Albert's Verdict
BPC-157 remains the most-studied gut-brain axis peptide in our catalog. The angiogenesis and nitric oxide pathway data across multiple independent labs is remarkably reproducible — that's rare in peptide research.
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Arrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
Product Description
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a portion of human gastric juice protein. It has been the subject of extensive preclinical laboratory research investigating actin-pathway signaling, angiogenesis, and gastrointestinal mucosa models.
Molecular Profile:
- Molecular Formula: C₆₂H₉₈N₁₆O₂₂
- Molecular Weight: 1,419.53 g/mol
- Sequence: GEPPPGKPADDAGLV
- CAS Number: 137525-51-0
Research Applications:
- Gastrointestinal mucosa cytoprotection research models
- Connective-tissue and musculoskeletal cellular research
- Osteogenic differentiation research models
- CNS pathway and neuroprotection research models
- Anti-inflammatory pathway investigation via the NO system
- Angiogenesis and VEGF signaling pathway research
Quality Standards:
- Purity: ≥99% verified by HPLC
- Third-party tested with Certificate of Analysis (COA) included
- Lyophilized powder form for stability during shipping
For laboratory handling instructions, refer to the Preparation Guide.
FOR RESEARCH USE ONLY. Not for human or animal consumption.
Technical Specifications
- Molecular Formula
- C62H98N16O22
- Molecular Weight
- 1419.53 g/mol
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
About BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protective protein found naturally in human gastric juice. Consisting of 15 amino acids with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, BPC-157 has emerged as one of the most extensively researched peptides in cellular-pathway research. Originally isolated by Professor Predrag Sikiric at the University of Zagreb, this peptide has been the subject of numerous preclinical investigations examining its potential protective and cellular-pathway properties in various tissue types.
Mechanism of Action
BPC-157's biological activity involves multiple interacting pathways that researchers believe contribute to its observed effects in experimental models:
Nitric Oxide System Modulation: Research suggests BPC-157 may interact with the nitric oxide (NO) system, potentially influencing blood vessel formation and cellular pathway processes. Studies indicate it may help regulate NO synthase activity.
Growth Factor Upregulation: Laboratory studies have observed increased expression of growth factors including VEGF (vascular endothelial growth factor), EGF (epidermal growth factor), and FGF (fibroblast growth factor) in BPC-157-treated tissue samples.
FAK-Paxillin Pathway: Research indicates BPC-157 may activate the focal adhesion kinase (FAK) pathway, which plays a crucial role in cell migration, adhesion, and tissue organization during healing processes.
Dopaminergic System Interaction: Studies suggest potential interactions with the dopaminergic system, which may explain some of the observed effects in neurological research models.
GABAergic System Effects: Some research indicates BPC-157 may influence GABA receptor function, contributing to its observed effects in gut-brain axis studies.
Research Highlights
Gastrointestinal Studies
BPC-157 was originally studied for its gastric protective properties. Research has examined its effects on various GI conditions in animal models, including gastric ulcers, inflammatory bowel conditions, and esophageal damage. Studies suggest it may promote mucosal integrity and accelerate healing in damaged GI tissue.
Musculoskeletal Research
Extensive preclinical studies have investigated BPC-157's effects on tendons, ligaments, and muscle tissue. Research in rat models has shown accelerated healing of transected Achilles tendons, quadriceps muscles, and various ligaments. Studies suggest enhanced collagen organization and accelerated functional recovery.
Wound-Model Research
Research has examined BPC-157's effects on various wound types, including burns, incisions, and diabetic wounds. Studies report enhanced angiogenesis (blood vessel formation), accelerated granulation tissue formation, and improved wound closure rates in experimental models.
Neurological Research
Emerging research has explored BPC-157's potential neuroprotective properties. Studies in animal models have examined effects on peripheral nerve injuries, traumatic brain injury, and various neurotoxicity models. Some research suggests potential dopaminergic system interactions.
Product Specifications
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ |
| Molecular Weight | 1419.53 g/mol |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Solubility | Soluble in water, bacteriostatic water |
| Storage | -20°C (lyophilized), 2-8°C (reconstituted) |
Research Usage Guidelines
Reconstitution Protocol
- 1Allow vial to reach room temperature (15-20 minutes)
- 2Use bacteriostatic water or sterile water for injection
- 3Add solvent slowly down the vial wall—do not spray directly on powder
- 4Gently swirl to dissolve—do not shake or vortex
- 5Solution should be clear and colorless
Storage Guidelines
- •Lyophilized: Store at -20°C, stable for 2+ years
- •Reconstituted: Store at 2-8°C, use within 4 weeks
- •Protect from light and repeated freeze-thaw cycles
- •For long-term storage of reconstituted peptide, aliquot into single-use portions
Frequently Asked Questions
BPC-157 is a synthetic 15-amino acid peptide derived from a naturally occurring protein in human gastric juice. It has been extensively studied in preclinical research for its potential protective and cellular-pathway properties in various tissue types.
Research References
- [1] Sikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157. Curr Neuropharmacol. 2016;14(8):857-865.
- [2] Seiwerth S, et al. BPC 157's effect on healing. J Physiol Pharmacol. 2018;69(6).
- [3] Gwyer D, et al. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159.
- [4] Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing. Int Orthop. 2011;35(3):421-426.
Learn More
Explore our comprehensive research guides for detailed information on peptide handling, storage, and research protocols.
Frequently Researched Together
Commonly studied alongside in laboratory settings
Research FAQ — BPC-157
Frequently asked questions about this compound for laboratory researchers.
What is BPC-157 and what does research suggest about its mechanism?+
What dosing has been used in published BPC-157 research?+
What is the reported half-life of BPC-157 in research literature?+
How should BPC-157 be stored in a research setting?+
Is BPC-157 third-party tested for purity?+
Published research references
Peer-reviewed literature relevant to BPC-157 research. Linked PubMed IDs open the original source.
- [1]BPC-157 and the gut-brain axis: a pleiotropic cytoprotective agent — Biomedicines (2021) · PMID 33391174
- [2]Pentadecapeptide BPC 157 enhances the healing process of the transected rat sciatic nerve — Regen Med (2014) · PMID 24426587
- [3]Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease — Curr Pharm Des (2012) · PMID 23012128
- [4]BPC 157 and standard angiogenic growth factors: gut healing and beyond — Pharmaceuticals (Basel) (2021) · PMID 34638391
Learn More About This Peptide
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.